A meta-analysis of genome-wide association studies identifies a new locus for age at onset in Parkinson’s disease

Takeaway

  • A meta-analysis of worldwide genome-wide association studies of Parkinson’s disease age of onset confirms importance of loci on chromosome 4.

Why this matters

  • There is a need to characterize genetic determinants of the age of onset of Parkinson's disease, including the validation of previously identified SNCA and TMEM175 loci on chromosome 4.

  • This meta-analysis in global genome-wide association studies not only validates previously identified loci but also identifies a novel locus, BST1; better understanding of the genetic determinants that modify disease progression will enable the development of treatments to delay the onset of Parkinson’s disease.