Abnormal brain structure and functional deficits precede clinical motor onset of adult-onset myotonic dystrophy type 1

Takeaway

  • Structural brain and functional changes occur in premanifest adult-onset myotonic dystrophy type 1 before the onset of clinically determined motor symptoms.

Why this matters

    This novel study identified brain and functional changes in premanifest myotonic dystrophy Type 1 that precede clinically determined motor symptoms. Identifying those individuals with abnormal white matter fractional anisotropy, poor finger-tapping and hypersomnolence could help to predict disease onset and improve interventional measures.