Cerebral microhemorrhage accumulation in heritable Alzheimer’s disease

Takeaway

  • Cerebral microhemorrhages (CMHs) form part of the underlying disease process in dominantly inherited Alzheimer’s disease (DIAD) and are significantly associated with dementia.

Why this matters

  • CMHs are commonly observed in older adults, but it can be difficult to discriminate etiology in this group since they often have mixed pathologies; as such, investigating CMH’s in a younger, at-risk cohort such as those with DIAD, may be useful.

  • The role of CMHs in DIAD may constitute a potentially important imaging marker of disease risk and may influence treatment options for patients as well as their selection in clinical trials for this specific condition; however, further study is warranted for greater clarity.