Diffusely abnormal white matter may predict progression of relapsing-remitting multiple sclerosis

Takeaway

  • Diffusely abnormal white matter (DAWM) and its changes may predict progression of relapsing-remitting multiple sclerosis (RRMS) in terms of burden of disease and brain atrophy, but not physical disability.

Why this matter

  • The natural history and prognostic significance of DAWM observed on MRI in RRMS is uncertain.