Diurnal cortisol variation is linked to later-life cognitive impairment

Takeaway

  • Hypothalamus-pituitary-adrenal axis dysfunction is associated with cognitive impairment in later-life.

Why this matters

    Loss of diurnal hypothalamus-pituitary-adrenal (HPA) axis variation could represent an early marker of cognitive impairment in later life and be a potential future target for disease modification in dementia.