Early beta-amyloid accumulation and neuroinflammation in dementia-free older adults


  • Neuroinflammation (NI) is associated with amyloid during early stages of amyloid-beta (Aβ) accumulation in a subgroup of dementia-free older adults.

Why this matters

  • Microglia become activated during NI and overexpress 18kDa translocator protein (TSPO), to which radioligands can bind during positron emission tomography (PET) imaging, providing insight of regions possibly involved in this process. NI is thought to play a role in Alzheimer’s disease (AD) pathogenesis, as are metabolic risk factors; however, there are mixed findings.

  • The complex relationship between metabolic factors, NI, Aβ accumulation and AD is highlighted, as is the need for larger, longitudinal studies for enhancement of clinical understanding and to inform specialized treatment development for high risk patients.