Intrathecal environment of huntingtin gene expansion carriers

Takeaway

  • In huntingtin (HTT) gene expansion carriers who do not yet show motor symptoms of Huntington’s disease (HD), there is a proinflammatory intrathecal environment, with elevated interleukin (IL)-17 and Th17.1 cells.

Why this matters

    This study indicated Th17.1 cells are involved in the very early disease stages of HD and may be a helpful therapeutic target for HTT gene expansion carriers.