Repeat lengths in the mutated Huntington gene are positively associated with cognitive performance in young adults

Takeaway

  • Prior to the onset of neurodegeneration, increasing CAG repeats in the Huntington gene are associated with improved cognitive performance in young adults.

Why this matters

    These important findings identify specific cognitive domains that are linked to CAG repeat length, as well as other domains that are unrelated to repeat length in young adults before they develop neurodegeneration. The findings highlight the role of the mutated huntingtin protein in neurodevelopment which could ultimately lead to better treatment strategies in Huntington's Disease.