Takeaway
Sensorimotor and cognitive domains modify their cerebellar functional connectivity in response to brain structural damage, even in the absence of disability.
Why this matters
The relationship between altered cerebellar functional connectivity and brain structural damage in multiple sclerosis has yet to be elucidated; this is the first study of functional connectivity alterations of cerebellar motor and cognitive domains, and their relationship with brain structural damage in cases without disability.
These important findings further our understanding of the clinical role of cerebellar functional connectivity alterations and whether these changes underlie a preserved clinical status despite brain structural damage; such information would ultimately support development of targeted therapies in early disease stages.