Serum neurofilament light chain levels reflect cortical degeneration in early relapsing-remitting multiple sclerosis

Takeaway

  • In newly diagnosed relapsing-remitting multiple sclerosis, the combination of cortical thickness and serum neurofilament light chain levels are biomarkers for early detection of cognitive impairment.

Why this matters

  • Although gray matter volume and cortical thickness have been implicated in cognitive dysfunction in multiple sclerosis, the role of serum neurofilament light chain levels as a measure of neuroaxonal injury remains unknown. These important findings suggest that the combination of biomarkers of both cortical macro- (cortical thinning) and microstructural (increased serum neurofilament light chain level) brain damage closely reflect subtle neurodegeneration changes; their presence could be the first signs of cognitive deficits in newly diagnosed relapsing-remitting multiple sclerosis.