Spatial patterns of dopamine transporter binding and multiple system atrophy subtypes

Takeaway

  • Spatial patterns of dopamine transporter (DAT) binding, as demonstrated by [18F]fluoro-propyl-carbomethoxy-iodophenyl-tropane ([18F]FP-CIT) positron emission tomography (PET), can reflect specific clinical features of multiple system atrophy (MSA).

Why this matters

  • It is thought that spatial patterns of neurodegeneration in striatal and extrastriatal regions may reflect various MSA clinical symptoms; however, this has not been clearly elucidated via in vivo studies, with MSA pathophysiology currently confirmed by autopsy.

  • The demonstration of DAT spatial patterns linked to clinical MSA phenotypes may have implications for targeted therapy development aimed at specific MSA subtypes; however, further study utilizing longitudinal and postmortem designs is required to validate this.