Study uncovers a novel regulatory role for neuregulin-1 beta 1 early in the disease course in multiple sclerosis and experimental autoimmune encephalomyelitis


Multiple sclerosis is characterized by immune mediated neurodegeneration that results in progressive, life-long neurological and cognitive impairments. Yet, the endogenous mechanisms underlying multiple sclerosis pathophysiology are not fully understood. Here, we provide compelling evidence that associates dysregulation of neuregulin-1 beta 1 (Nrg-1β1) with multiple sclerosis pathogenesis and progression. © 2021 Guarantors of Brain. Published by Oxford University Press on behalf of the Guarantors of Brain. Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries. Published in the United States by Oxford University Press USA, New York. This article is published with permission from Oxford University Press.
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